Bikul Koirala's Summary
Experienced biotechnology professional with a strong track record of analytical method development and documentation, analytical equipment acquisitions, maintenance, and repair. Experienced in sterile anaerobic fermentations Interested in the renewable energy and biobased chemical industry.
Specialties
• GC, HPLC, GC-MS, LC/MS method development and optimization • Fermentation development and optimization for production of biobased chemicals. • Process scale-up and scale-down • Analytical equipment installation, operation, and maintenance • QA/QC setup
Bikul Koirala's Skills & Expertise
Bikul Koirala's Experience
Research Associate
OPX Biotechnologies, Inc.
Privately Held; 51-200 employees; Biotechnology industry
November 2011 – Present (9 months) Boulder, CO
Research Associate
Tetravitae Bioscience
Privately Held; 11-50 employees; Biotechnology industry
March 2009 – October 2011 (2 years 8 months) Champaign, IL
• Develop and Perform lab-scale and pilot scale experiments aimed at optimizing the methods and equipment of fermentation(Corn, Sugercane, Municipal Waste) and product isolation • Downstream purification design and optimization of fermentation products. • Lead analytical method development and instrument acquisition (GC, HPLC, LC-MS) critical to experimental efforts • Researched and performed ASTM testing on final fermentation products( Acetone, Butanol) to prepare industry standard product spec sheets • Identified and developed a novel catalyst systems for the production of guerbet alcohols • Train technicians in execution of routine analyses and new methods and instruments • Assist in formulation of research goals through study of literature, engaging in discussion of research results and proposing experimental efforts. Organize, analyze and summarize experimental results • Prepare and maintain standard operating procedures (SOP)
Analytical Consultant
Tetravitae Bioscience
Privately Held; 11-50 employees; Biotechnology industry
October 2008 – March 2009 (6 months)
• Consulted in analytical method development and instrument acquisition (GC, HPLC) • Prepared and maintained standard operating procedures for analysis of fermentation substrates and products
Analytical Chemist
Isotech Labrotaries
August 2008 – March 2009 (8 months)
• Gas and liquid sample preparation for stable Isotope ratio analysis (C,H,N,S,O) • Isotopic analysis of groundwater and surface samples • • Operation and maintenance of Isotope ratio Mass spectrometer
Teaching Assistant
Idaho State University
Educational Institution; 1001-5000 employees; Higher Education industry
January 2006 – August 2008 (2 years 8 months)
Labs taught include General Chemistry; Introduction to General Chemistry, Organic and Biochemistry, and Quantitative Analysis.
Undergraduate and Graduate Research Assistant
Idaho State University
Educational Institution; 1001-5000 employees; Higher Education industry
July 2005 – August 2008 (3 years 2 months)
Use of GC-MS techniques for identification of archeological samples via extraction, transesterification, and analysis of fatty acids to determine the source(s) of the residue with the view of increasing our understanding of history and civilization of particular geographical area. Supervisor, Dr. Jeffrey Rosentreter.
Research Assistant
Idaho State University
Educational Institution; 1001-5000 employees; Higher Education industry
March 2005 – August 2008 (3 years 6 months)
•Performed laboratory research on Behavioral and neurochemical studies of ethanol dependence and withdrawal in a lab animal model using techniques including Gamma Counter, Radioimmunoassay, Western Blotting, Liquid Chromatography Mass Spectrometry, Immunocytochemistry, Mammalian hippocampal slice culture brightfield and Fluorescent microscopy • Wrote technical papers, reports, and standard operating procedures (SOP) • Presented findings in regional and national meetings, and prepared manuscripts for publications • Played active role in design and co-ordination of experiments and personnel scheduling
Program Residence Coordinator
Idaho State University
Educational Institution; 1001-5000 employees; Higher Education industry
January 2005 – December 2005 (1 year)
My duties included welcoming ELS students to Idaho State University, managing their accommodation, providing them with local and campus information, matching them with interested residents as roommates so as to better help them learn English, and helping them cope with the language, cultural, and traditional changes.
Bikul Koirala's Education
Idaho State University
Master of Science, Chemistry , ACS certified Chemist
2007 – 2008
ACS Outstanding Analytical Chemist Award
Activities and Societies: American Chemical Society
Idaho State University
Bachelor of Science, Biochemistry and Chemistry (ACS certified Chemist)
2003 – 2007
Activities and Societies: American Chemical Society Snake River Association of Neuroscience
Bikul Koirala's Publications
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Examination of prehistoric artifacts via fatty acid methyl ester (FAME) techniques using modern environmental stewardship
- Journal of Archaeological Science
- June 2009
Authors: Bikul Koirala, Jeffrey RosentreterElucidating the specific use and purpose of archaeological specimens such as stone axes and grinding stones can improve the understanding of an area's ecosystem and civilization. Chemical analysis of residues preserved on these tools may provide key information in identifying how the tool was implemented. The arid US Great Basin provides an ideal environment for the preservation of fatty acid...more
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Influence of hormonal status on behavioral responses to an acute ethanol challenge during ethanol withdrawal in male and female rats
- Pharmacology Biochemistry and Behavior
- October 2008
Authors: Bikul Koirala, Paul E. Alele, Leslie L. DevaudWe previously reported significant sex differences in ethanol withdrawal (EW) recovery as well as in sensitivity to GABAA receptor modulators during EW. The aim of the present study was to determine if hormonal status moderated behavioral responses to an acute ethanol challenge in EW animals comparing two different behaviors. An initial set of experiments explored motor-incoordinating effects of...more
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Sex Differences in Acoustic Startle Responses and Seizure Thresholds between Ethanol-Withdrawn Male and Female Rats
- Alcohol and Alcoholism
- November 2009
Authors: Bikul Koirala, William Reilly, Leslie L. DevaudAims: We have found consistent and significant sex differences in recovery from the increased seizure susceptibility observed during ethanol withdrawal (EW) in our rat model system. The main objective of the present study was to determine if sex differences in EW generalized to an additional behavioral measure startle reactivity. Methods: Acoustic startle or seizure threshold responses were...more
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